The little guy includes the small corporation, the newbie player. The players that will shape Eve in a couple of years time.
Conventional wisdom says that new players should either remain in highsec or be absorbed into large null structures (and be bound by them); with lowsec being a place for those with some experience to eat newbies for breakfast.
There is a 4th space : wormhole systems. Sure; I would not recommend that a beginner one month old pilot try to form a wormhole corp. Mind you, after a month I was still toying with starter missions and discovering a whole new universe.
For the wannabe new corporation: you do need some skills; Anchoring to set up a POS; Scanning to find your way home; an industrial ship or 3 to bring 'stuff' in. (There is no market in WH space with the exception of what you make with your fellow residents.).
Wormholes are for moderately active groups; You would probably want 3 or 4 accounts even in a "Class 2" wormhole (whether 4 players or 1 very organised one). You need someone capable of remembering to keep the lights turned on (otherwise known as hauling fuel blocks or at least the ice products for those).
In wormholes there is always something to do: Planetary Interaction; combat sites; mining sites; running away from PVP roams; maybe even doing PVP roams; raiding your neighbour's sites.
Wormholes do have a home advantage. You have a large defensive structure to run away to (your POS). If you are organised: it has replacement/alternative ships; spare ammo; salvaging equipment.
There is a limit to the amount and size of ships that can be brought into a wormhole. Are you a young group and the idea of a battleship scares the goo out of your pod? Set up in a class 1 wormhole.
Other groups might be content to see a battleship but not want to take on a Dreadnought or Carrier. In that case a Class 2-4 Wormhole system might be for you.
It is also difficult to take a huge number of high dps ships on a roam; especially in the lower class wormhole systems. You can take a few; but to bring in enough DPS to roflstomp a POS in a lower class wormhole system will simply collapse the entry wormholes instead. Defenders have plenty of time to bring in what ships they like; and can even build ships that are too big to take in our out.
Now; like everything else in Eve; nothing is 100% safe. WH roams can still ruin your day. Even a 'dickstar' POS can be broken despite the lack of capital ships if the attackers are determined enough.
That said, a class 2 wormhole is a great place to practice sovereignty by occupation.
Some recent WH blog posts include :